Research Project

Exercise timing for optimal glucose control in type 2 diabetes

Principal Investigator
Calik, Michael W.
Funding Source
Internal Research Support Program

Abstract

There is no consensus in humans on the optimal timing of meals and exercise for glucose control. Moreover, there are no preclinical studies that investigated the role that meal timing, exercise and sleep play in glucoregulation. This preclinical study will be the first to look at all three factors of meal consumption, exercise and sleep and how they affect glucoregulation (e.g. body mass, fat mass, levels of insulin, and glucose). Zucker Lean (normal control) and Zucker Obese (prediabetic) rats will be fed on a fixed schedule so that they eat before (postprandial) or after (preprandial) a bout of moderate intensity treadmill exercise. Feasibility data on exercise without modifying meal timing (rats fed ad libitum) confirms that ZO rats gained more weight than Zucker lean, and that 2 weeks of exercise seemed to normalize the sleep pattern of ZO rats. The funds from the IRSP will be used to collect data on rats that will have modified feeding schedule, and exercise or no exercise. More importantly, body mass via weight scale and fat mass via MRI will be collected, along with metabolic markers in plasma (insulin and glucose) These data will be used to apply for several areas of funding including R01 and R21 grant mechanisms.