Mark Lockwood, PhD, MSN, RN
Biobehavioral Health Science
Building & Room:
845 S. Damen Ave., MC 802, Chicago, IL 60612
My research program has four main components: 1) advancing symptom science through the identification of symptom clusters in patients with chronic kidney disease, 2) Exploring the effects of the gut microbiome on symptoms and adverse outcomes in pre-and post-kidney transplant recipients, 3) Continuing work understanding the nuances of information and communication technology use among patients with chronic illness, and 4) Reducing existing health disparities/inequities by developing of innovative strategies leveraging other areas of my research program.
My research program takes an ‘omics’ approach to medication adherence. High patient symptom burden, including depression and anxiety-like symptoms have been linked to medication non-adherence among post-kidney transplant patients. In addition, there is a clear link between disruptions in the gut microbiome, also known as dysbiosis, and behavior via the brain-gut microbiome axis. It is known that antibiotic, antivirals, and immunosuppressant medications alter the relative abundance of these beneficial bacteria. We have begun work exploring relationships between disruptions in the oral/gut microbiota that result from exposure to antibiotics, immunosuppression, and stress from the transplant surgery, the patient’s symptom burden, and medication adherence in a prospective study of patients with end stage renal disease who progress to kidney transplantation. This work is being done in conjunction with Dr. Stefan Green and colleagues at the DNA Services Laboratory at UIC. Our research will compliment efforts that focus on behavioral, psychosocial, and environmental causes of medication non-adherence by exploring underlying biological mechanisms for non-adherence, including medication taking behaviors that may be linked to the brain-gut-microbiome axis.
International Transplant Nurses Society, A Prospective Study to Assess Psychosocial Factors that Influence Completion or Non-completion of the Pre-Renal Transplant Evaluation at an Urban Transplant Cente, PI
International Transplant Nurses Society, Determining Predictors of In-home Internet Access and the Use of Personal Health Record (PHR) Systems in an Urban End Stage Kidney Disease (ESKD)/Post-kidney Transplant Population in the United States, PI
The Honors Society of Nursing: Sigma Theta Tau, Information and Communication Technology (ICT) Use in Pre and Post Renal Transplant Patients at an Urban Transplant Center, PI
Univeristy of Illinois at Chicago College of Nursing, Changes in Oral and Gut Microbiota, Symptom Burden, and Medication Adherence in Pre- and Post-Kidney Transplant Patients, PI
11. Lockwood, M.B., Chung, S., Bronas, U.G., Ryan, C., Puzanian, H., Park, C., & DeVon, H. (2018). Symptom Cluster Science and Outcomes in Chronic Kidney Disease: A Review of the Literature. Western Journal of Nursing Research. (accepted September 26, 2018).
*10. Maki, K.A., ADiallo, A.F., Lockwood, M.B., Franks, A.T., Green, S.J., Jospeh, P.V. (2018). Considerations When Designing a Microbiome Study: Implications for Nursing Science. Biological Research for Nursing, (accepted for publication 8/28/18).
*9. Lockwood, M.B., Dunn-Lopez, K, Pauls, H., Burke, L., Shah, S., & Saunders, M.A. (2018). If You Build It, They May (or May Not) Come: Modifiable Barriers to Patient Portal Use Among Pre-and Post-Kidney Transplant Patients. (Accepted to JAMIA Open, May 2018).
*8. Lockwood, M. B., Dunn-Lopez, K., Burke, L., Becker, Y. T., & Saunders, M. (2017). Frequency of In-Home Internet Use Among Prekidney and Postkidney Transplant Patients—Facilitators and Barriers to Use and Trends Over Time. Transplantation Direct, 3(11), e216. doi:10.1097/txd.0000000000000735
*7. Lockwood MB, Saunders MR, Nass R, McGivern CL, Cunningham PN, Chon WJ, et al. Patient-Reported Barriers to the Prekidney Transplant Evaluation in an At-Risk Population in the United States. Progress in Transplantation (Aliso Viejo, Calif). 2017;27(2):131-8. Epub 2017/06/16. doi: 10.1177/1526924817699957. PubMed PMID: 28617167.
*6. Lockwood, M.B., Bidwell, J., Werner, D., & Lee, C.S. (2016). Non-biological barriers to referral and the pre-kidney transplant evaluation among African Americans in the United States: A systematic review. Nephrology Nursing Journal, 43(3), 225-238.
*5. Lockwood, M., Saunders, M., Josephson, M, Becker, Y., & Lee, C. (2015). Determinants of frequent Internet use in an urban kidney transplant population in the United States: Characterizing the digital divide. Progress in Transplantation, 25(1), 1-9.
*4. Lockwood, M.B., Saunders, M. Lee, C.S., Becker, Y.T., Josephson, M.A., and Chon, W.J., (2013). Renal Transplantation and the Digital Divide: Does Information and Communication Technology Represent a Barrier or a Bridge to Transplantation for African Americans? Progress in Transplantation, 23(4), 302-9. DOI: 10.7182/pit20113869.
*3. Khoury JA, Storch GA, Bohl DL, Schuessler RM, Torrence SM, Lockwood MB, Gaudreault-Keener M, Koch MJ, Miller BW, Hardinger KL, Schnitzler MA, Brennan DC: Prophylactic versus preemptive oral valganciclovir for the management of cytomegalovirus infection in adult renal transplant recipients. American Journal of Transplantation, 2006; 6: 1-10.
*2. Hardinger KL, Bohl D, Schnitzler MA, Lockwood MB, Storch GA, Brennan DC: A randomized, pharmacoeconomics trial of tacrolimus versus cyclosporine in combination with Thymoglobulin in renal transplant recipients. Transplantation, 2005; 80: 41-46.
*1. Brennan DC, Agha I, Bohl DL, Schnitzler MA, Hardinger KL, Lockwood MB, Torrence S, Schuessler R, Roby T, Gaudreault-Keener M, Storch GA: Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction. Am J Transplant, 5:582-594, 2005.
1. Tambur AR, Herrera N, Lockwood M, Abecassis M: Mycophenolate Mofetil as a tool to alter dendritic cell maturation and allo-antigen presentation. 2004 World Transplant Congress, Poster.
2. Brennan DC, Hardinger KL, Bohl DL, Lockwood MB, Torrence S, Schuessler R, Gaudreault M, Roby T, Koch MJ, Miller BW, Schnitzler MA, Storch GA: Preemptive vs prophylactic valganciclovir for CMV in renal transplantation: Early results from a randomized, prospective trial. American Society of Nephrology 2004, St. Louis, MO, J Am Soc Nephrol 15, Abstract SA-FC009 pp 23A, 2004.
Co-Chair, EBP & Research Council, Univeristy of Chicago Medicine
Director at Large (Board of Directors), International Transplant Nurses Society
Chair, Memebership Task Force, International Transplant Nurses Society
Chair, Faculty Search Committee, UIC College of Nursing
2018, Janet A. Deatrick Award, UIC College of Nursing
2018, Distiguished Service Award, International Transplant Nurses Society
2017, Fellow, NINR Summer Gentics Institute
2016, Distinguished Service Award, Univeristy of Chicago Medicine
Jewish Hospital College of Nursing 1995/1997 Nursing
and Allied Health (ASN/BSN)
Loyola University at New Orleans 2010 Nursing (HCSM)
Oregon Health and Science 2016 Nursing Science
2017 Member, American Society of Transplantation
2017 Member, The Transplantation Society
2017 Member, American Nephrology Nurses’ Association
2010 Member, The Honors Society of Nursing, Sigma Theta Tau International
2009 Member, International Transplant Nurses Society
2005-2018 Association of Clinical Research Professionals
2009-2016 Co-chair, University of Chicago Nursing Evidence-Based Practice and Research Council
2009-2010 Gift of Hope, African American Task Force
2000-2004 Human Studies Committee, subcommittee member, Washington University at St. Louis
2018 International Transplant Nurses Society Symposium, Transplant Nurses: Leaders in Excellence. September, 2018, “Patient Portal Use Among Pre- and Post-Kidney Transplant Patients at an Urban Transplant Center in the United States”. Chicago, IL. Oral Presentation.
2018 International Transplant Nurses Society Symposium, Transplant Nurses: Leaders in Excellence. September, 2018, “Why I went to the NINR’s Summer Genetics Institute and why you should too!”, Chicago, IL. Oral Presentation.
2018 American Transplant Congress, June 2-6, 2018, Facilitators and Barriers to Patient Portal Use among Pre- and Post-Kidney Transplant Patients at an Urban Center in the United States, Seattle, WA, Poster presentation.
2018 Midwest Nursing Research Society Annual Conference, Chung, S.Y. & Lockwood, M. “Symptom Clusters in Patients with Chronic Kidney Disease: A Review of Literature”, Cleveland, OH, April 12-15, 2018. (Oral Presentation, presented by Dr. Chung).
43nd Biennial Convention, Honors Society of Nursing: Sigma Theta Tau, October 2017 “In-Home Internet Use Increases as the Number of Internet Users in the Household Increases”. Indianapolis, IN, Oral Presentation.
2017 International Transplant Nurses Society Symposium, Reflections of Transplant Nursing Excellence. June, 2017, “Using Lean Management Philosophy to Develop a Plan for a One-day Pre-kidney Transplant Evaluation at an Urban Transplant Center in the United States via a Kaizen Event ”, Orlando, FL. Oral Presentation (presented by Patrice Pfeiffenberger, BSN, RN).
2017 American Transplant Congress, April 26-May 3, 2017, “Patient-reported Barriers to the Pre-kidney Transplant Evaluation in an At-risk Population in the United States“. Chicago, IL, Poster presentation
2016 International Transplant Nurses Society Symposium, Transplant Nursing: Bridging passion, practice, and patient care. October 13, 2016, “Let ITNS Help Take Your Career to the Next Educational Leve: Leadership, Mentoring, and Career Development in Transplant Nursing”, Pittsburg, PA. Pre-symposium Program, (developed in conjunction with Laura Taylor, PhD, RN, ANEF, Cynthia Russell, PhD, RN, FAAN, Donna Hathaway, PhD, RN, FAAN, Catherine Pantik, RN, and Justin Bilik, RN).
2016 International Transplant Nurses Society Symposium, Transplant Nursing: Bridging passion, practice, and patient care. October 16, 2016, “Determining Predictors of In-home Internet Access and Use of Personal Health Record (PHR) Systems in an Urban End Stage Kidney Disease (ESKD)/Post-kidney Transplant Population in the United States”, Pittsburg, PA. Oral Presentation, (Plenary session).
2016 American Transplant Congress, June 11-15, 2016, “Prospective Randomized Controlled Study Evaluating the Impact of an Electronic Feedback System (EFS) on Medication Adherence in Solid Organ Transplantation”, Boston, MA, Oral presentation
2016 American Transplant Congress, June 11-15, 2016, “Randomized Controlled Study Evaluating Adherence Monitoring with Electronic Feedback on Reducing Renal Allograft Rejection”, Boston, MA, Oral presentation
2016 American Transplant Congress, June 11-15, 2016, “Prospective Randomized Controlled Study Evaluating the Relationship Between Electronic Adherence Data and Tacrolimus Concentration Data”, Boston, MA, Poster presentation
Sigma Theta Tau International's 26th International Nursing Research Congress, July 23, 2015, "There's an app for that, is there an audience for that?: Determinants of Smartphone ownership and comfort of use in an urban pre and post renal transplant population", San Juan, Puerto Rico, Oral presentation.
2015 International Transplant Nurses Society Summer Symposium, Transplant Nursing: A Journey to the Top/ June 12, 2015, “Nonmedical Barriers for African Americans Associated with Referral and the Pre-kidney Transplant Evaluation in the United States: A Synthesis of the Literature”, Chicago, IL, Poster presentation
2015 International Transplant Nurses Society Summer Symposium, Transplant Nursing: A Journey to the Top. June 13, 2015, “Objective and Subjective Barriers to the Pre-kidney Transplant Evaluation.” Chicago, IL. Oral Presentation, (Plenary session).
Nursing Grand Rounds, University of Chicago, November, 2014, “How to conduct a synthesis of the literature”, Chicago, IL. Lecture.
23rd Annual International Transplant Nurses Society Symposium, One World of Caring, September 27, 2014, “Determinants of Internet Use at an Urban Transplant Center: Characterizing the Digital Divide.”, Houston, TX, Oral Presentation.
42nd Biennial Convention, Honors Society of Nursing: Sigma Theta Tau, November 2013 “Renal Transplantation and the Digital Divide: Does Information and Communication Technology Represent a Barrier or a Bridge to Transplantation for African Americans?, Indianapolis, IN, Oral Presentation.
Research Currently in Progress
Lockwood, M.B. (PI). Characterizing Symptoms Cluster across the Spectrum of Chronic Kidney Disease Using Data from the Chronic Renal Insufficiency Cohort Study (CRIC).
Lockwood, M.B. (PI). Changes in Oral and Gut Microbiota, Symptom Burden, and Medication Adherence in Pre- and Post-Kidney Transplant Patients.