Research Project
Plasma Lipid Profiles, Symptoms, and Outcomes Following Acute Ischemic Stroke
The purpose of this study is to determine the feasibility of a 1-month protocol and to describe self-reported symptoms and their association to cognitive and functional outcomes in persons with AIS who did and did not receive reperfusion intervention. We will explore these factors and their association to underlying lipid biomarker signatures.
- Principal Investigator
- Martha, Sarah R.
- Start Date
- 2022-07-01
- End Date
- 2023-06-30
- Funding Source
- Agnes Marshall Walker Foundation
Abstract
The purpose of this Agnes Marshall Walker Foundation Research Grant is to support a research assistant for Dr. Sarah Martha’s NIH/NINR K23 Award. Dr. Martha is an Assistant Professor at the University of Illinois at Chicago, College of Nursing. Acute ischemic stroke (AIS) is the leading cause of severe long-term disability in the United States. AIS is characterized by the disruption of cerebral blood flow due to large arterial occlusion, caused by a cerebral thrombus. Half of AIS survivors exhibit fatigue and depressive symptoms, cognitive deficits, and poorer functional outcomes. Recent advances in omics methodology enables lipidomic profiling, which may provide knowledge of the underlying pathology of AIS and its associated symptoms and outcomes. The proposal aims are to: 1) Examine the feasibility and accessibility of an 1-month protocol to assess symptoms, cognitive and functional outcomes, and lipidomic sample collection procedures among AIS participants; 2) Separately, within each subgroup of AIS (reperfusion and non-reperfusion), to describe symptoms and their association with cognitive, functional outcomes (study day 5 and 1-month); and 3) Explore the relationship between peripheral plasma lipid levels (study days 1, 3, 5 and at 1-month) with symptoms, cognitive and functional outcomes (study day 5 and 1-month) within each subgroup of AIS (reperfusion and non-reperfusion).