The aim of this study, the Follow-Up After Sedentary Reducing Intervention (FASRI) Study, is to investigate the feasibility of post-intervention follow-up and the preliminary efficacy of a sedentary reducing intervention to lead to sustained decreases in sedentary time in a diverse, representative sample of adults with CKD.
The proposed research tests the effectiveness of an evidence-based model of group antenatal care, compared to individual (usual) antenatal care. We simultaneously identify the degree of successful implementation success and factors associated with success across 6 antenatal clinics in Blantyre District, Malawi. If results are negative, governments will avoid spending on ineffective care. Positive maternal, neonatal and HIV-related outcomes of group antenatal care will save lives, impact the cost and quality of antenatal care, and influence health policy as governments adopt this transformative model of care nationally.
National Center for Advancing Translational Sciences
Project Duration
2020-09-21 — 2025-08-31
Sickle Cell Disease patients are living with a high burden of pain and high prescription opioid use. There are three priorities for this study: (1) evaluate the effectiveness of guided relaxation and acupuncture to improve pain control; (2) determine what is the most appropriate and effective treatment sequence for any given patient based on unique characteristics; and (3) describe the processes and structures required to implement guided relaxation and acupuncture into health care systems. Results from this research may reduce opioid use and improve pain management among sickle cell disease patients.
Chronic kidney disease (CKD) effects 1 in 7 adults in the U.S., with higher rates among racial and ethnic minority patients. Early-stage CKD patients often have no symptoms, however, progression to kidney failure has an enormous impact on quality of life, risk of death, and healthcare costs. Adhering to recommendations for medication, diet, and exercise are critical to slowing CKD progression, but many patients struggle with adherence. Recognizing patients as an important member of the care team allows the person to provide crucial insights about their unique perceptions and preferences to inform treatment. However, primary care providers (PCPs) face barriers to tailor care to patients, including a lack of time and resources...
Transfer application: Acute ischemic stroke (AIS) is the leading cause of long-term disability in the US, and about 50% of AIS survivors exhibit fatigue and depressive symptoms, cognitive deficits, and poorer functional and health-related quality of life outcomes. The proposed project will examine biological mechanisms associated with symptoms and outcomes in AIS survivors.
Low-income populations are disproportionately burdened by tobacco use and carry a greater burden of pulmonary health inequalities related to smoking. Despite widespread usage by populations burdened by tobacco use, Federally Qualified Health Care (FQHC) systems are an under-utilized model for reducing pulmonary and other smoking-related health inequalities among disadvantaged populations. The purpose of this study is to demonstrate the feasibility, effectiveness, and cost-effectiveness of electronically delivered smoking cessation interventions via patient portals in a network of FQHC clinics.
Background: Maternal adverse childhood experiences (ACEs, e.g., abuse, neglect, household dysfunction, community-level violence) are an important root cause of health and social problems and can increase risk for mental and physical health problems during the perinatal period. Women from marginalized groups are disproportionately exposed to ACEs and other structural inequities, such as segregation, poverty, crime, and violence, and reduced access to healthy foods and heath care. Objective: This proposal explores feasibility and acceptability of a resilience- and trauma-informed care (RTIC) approach to prenatal care among under-resourced pregnant women by gathering stakeholder perspectives to guide development and implementation of RTIC in community health centers...
Our research team pioneered the multivariable artificial pancreas (mvAP) that uses physiological and continuous glucose monitoring (CGM) data to mitigate the effects of meals and exercise without any manual inputs. Our mvAP has performed successfully in clinical experiments. We have also collected data in experiments with various types of physical activities and acute stress inducements and developed classification and intensity estimation algorithms for these activities using machine learning. Our multidisciplinary team includes endocrinologists, nurse researchers, biomedical engineers, exercise physiologists, behavioral scientists and statisticians. The overall objective of this proposal is to develop mvAP technology that addresses physical activity and stress-related challenges and complex situations such as their concurrent occurrence.
Building on the success of our initial Phases, in the fifth Phase of this project, the NExT team has four objectives: 1) Expand the online NExT modules to include evidence-based practice content applicable to all public health professionals while continuing outreach to public health, school health, acute, and ambulatory care nurses; 2) Create an additional website link and path for the public health professional modules; 3) Continue and extend marketing/promotion of EBP to underserved community hospitals, health departments, and clinical agencies across the state, NNLM Region 6 area, and nation by targeting these institutions and specific national nursing and public health organizations and associations; 4) Continue the current public health and school health and acute and ambulatory care module design, navigation, social media presence and access to all nursing EBP modules and 5) Provide continuing education units for librarians, public health professionals, practicing acute/ambulatory care and public/school health nurses.
The COVID19 pandemic may exacerbate maternal health inequities by disrupting obstetric care, increasing maternal stress and amplifying structural violence against Black women. In Chicago, maternal morbidity and mortality is 6 times more likely among Black birthing people than white, despite policy initiatives to promote maternal health equity. Disparities in maternal morbidity and mortality reflect experiences of structural violence in health care -- including limited patient-centered care, insufficient coordination and continuity of care, and implicit bias resulting patient mistrust in the health care system, low engagement, and attendance in perinatal care...
Hypertension and obesity are both major risk factors for cardiovascular disease (CVD), a leading cause of death for Black women in the United States. Obesity and hypertension can be prevented or controlled with diet for Black populations, as evidenced in the DASH, ENCORE, and PREDIMED trials. However, lack of access to affordable healthy foods in the neighborhood environment contributes to poor diet quality. In Chicago, obesogenic food environments in segregated Black communities have contributed to disparate access to healthy foods. In addition, Federally Qualified Health Centers (FQHCs), which play a significant role in healthcare delivery for Black Americans, are more likely to be in medically underserved communities, and key social determinants of health such as low income, food insecurity and poor food access are more prevalent...
The goal of this project is to assess the feasibility of engaging Black male caregivers in family based STI/HIV intervention programming. Findings from this study will facilitate the adaption of an evidence based intervention.
National Center for Advancing Translational Sciences
Project Duration
2021-09-28 — 2024-08-31
This K24 investigator award will provide 25% support for Dr. Ardith Doorenbos to (1) promote the development and retention of junior scientists in independent careers in patient-oriented research related to providing effective non-opioid options for the treatment of pain conditions; (2) expand and strengthen important leadership and mentorship skills; and (3) further her own line of patient-oriented research in pain and symptom science. The K24 funding will support active, productive participation in leading and mentoring patient-oriented research opportunities that are currently in progress or can be realized in the next few years. These activities aim to develop new information relevant to clinical practice and public policy
National Institute of Child Health and Human Development
Project Duration
2017-09-11 — 2024-05-31
This proposed research will refine and prospectively validate the effectiveness of quantitative ultrasound (QUS) technology [QUS parameters: cervical ultrasound attenuation coefficient (ATTEN), cervical ultrasound backscatter coefficient (BSC)], when compared to ultrasound (US)-estimated cervical length (CL), to identify women at-risk for spontaneous preterm birth (sPTB).
National Institute of Diabetes, Digestive & Kidney Disorders
Project Duration
2020-07-01 — 2025-04-30
Up to 40% of adults with type 1 diabetes have insufficient sleep (less than 6.5 hours per night) which is associated with negative health consequences including poor blood glucose control and greater diabetes complications. We propose a sleep intervention (Sleep-Optimize) that uses wearable sleep tracking technology, telephone coaching and informational content designed to improve sleep and glycemic control. Sleep-Optimize could lead to reduced development of diabetes complications and improve quality of life for adults with type 1 diabetes.
National Institute of Diabetes, Digestive & Kidney Disorders
Project Duration
2023-05-15 — 2028-02-29
People with end-stage kidney disease may experience moderate to severe pain as a result of the inability of their kidneys to filter toxins that cause inflammation, and for many pain persists after restoration of kidney function following kidney transplantation. We all coexist with trillions of bacteria and other microbes, collectively known as the microbiome, that live in communities on and within the human body and make chemicals that reduce or exacerbate pain through the brain-gut-microbiome-axis. The goal of this study is to better understand how the communities of microbes, and the chemicals they produce that may affect pain, change after kidney transplantation, and how these changes affect pain over time in order to develop patient-centered treatments for pain by manipulating the microbiome through diet, stress reduction, and or supplementation with pre/probiotics
National Institute of Diabetes, Digestive & Kidney Disorders
Project Duration
2019-09-24 — 2024-05-31
The purpose of this study is to evaluate novel strategies to reduce opioid use and pain in HD patients. Specifically, we will examine the effect of non-pharmacologic and pharmacologic (buprenorphine) interventions in HD patients who are receiving chronic opioid medications (>90 days/year) due to chronic pain (>3 months duration) and/or high pain interference. The proposed study will follow a quantitative Sequential Multiple Assignment Randomized Trial (SMART) design.
The specific aims are to (1) conduct a qualitative analysis of semi-structured interviews with religious leaders to identify barriers and facilitators to discussing ACP and death-related topics among Asian Americans with cancer; (2) conduct a usability test of a culturally tailored digital resilience-building intervention prototype to collect feedback on the intervention’s content using think-aloud interviews with Asian American patients with cancer and family caregivers; and (3) conduct a process evaluation to determine the feasibility, acceptability, and appropriateness of the intervention prototype. The expected outcomes are identification and development of the essential components of the intervention and data that contribute to a revised version of the intervention to be optimized in future research that follows the second phase of MOST.